Development of the decision tree model for distinguishing individuals of Chinese four surnames from Zhanjiang Han population based on Y-STR haplotypes

Co-separation studies between surnames and Y chromosome genetic markers are beneficial to revealing population migrations, surname origins, population formation histories and forensic familial searching. Genetic distributions of 27 Y-STRs in Chinese four surnames (Li, Lin, Chen and Huang) from Zhanjiang Han population were investigated. Meanwhile, we tried to develop a decision tree model for surname predictions based on Y-STR haplotypes. Allelic frequencies of 27 Y-STRs showed that unique alleles were only observed in a certain surname; besides, some alleles displayed higher frequencies in a certain surname than those in other surnames, implying these alleles might be employed as the useful indicators for surname predictions. Haplotype match probability values of 27 Y-STRs in these surnames revealed that the system could be used as a valuable tool for forensic male identification. The developed decision tree model performed well for the training set with the accuracy of 0.9860 and obtained the relatively high accuracy (>0.70) for surname predictions of the testing set. To sum up, we explored the power of the machine learning to the surname predictions based on obtained Y-STR haplotypes, which showed promising application values in forensic familial searching.     

Systematic Searching and Selection of Health State Utility Values from the Literature

Health state utility values (HSUVs) are important parameters in decision models in health technology assessment submissions. Reimbursement agencies, such as the National Institute for Health and Clinical Excellence, recognize that such values are obtainable from the published literature. However, to use published values in health technology assessment submissions, it should be demonstrated that HSUVs have been identified and selected systematically to avoid using biased HSUVs resulting in cost-effectiveness analyses. This article presents guidance on how to conduct a systematic literature review to identify and select HSUVs from the published literature based on the authors’ experience. A case study is used to demonstrate some of the features of a systematic HSUV review. Methods are discussed in relation to identifying and selecting the evidence, performing quality and relevance assessment, and undertaking data extraction. It has been developed from a Technical Support Document produced for the National Institute for Health and Clinical Excellence by the Decision Support Unit at the School of Health and Related Research, University of Sheffield.     

Identification of 4‐aryl‐1H‐pyrrole[2,3‐b]pyridine derivatives for the development of new B‐Raf inhibitors

During the last years, a significant interest in the identification of new classes of B‐Raf inhibitors has emerged. In this study, which was conceived within an effort that culminated in the recent report of the first dual inhibitors of B‐Raf and Hsp90, we describe the identification of four compounds based on 4‐aryl‐1H‐pyrrole[2,3‐b]pyridine scaffold as interesting starting points for the development of new B‐Raf inhibitors. Structure–activity relationships and predicted binding modes are discussed. Moreover, the novelty of the newly identified structures with respect to currently known B‐Raf inhibitors was assessed through a ligand‐based dissimilarity assessment. Finally, structural modifications with the potential ability to improve the activity toward B‐Raf are put forward.     

我国高校教师职业倦怠的元分析

目的考察高校教师的职业倦怠状况是否随年代变化,为高校和教育主管部门干预职业倦怠提供理论参考。方法通过检索中国知识资源总库-CNKI系列数据库,采用元分析方法对我国教师职业倦怠情况进行研究。结果年代与高校教师职业倦怠的情绪衰竭因子、非人性化因子和低成就感因子呈显著正相关(r=0.11,0.151,0.136;P0.01),年代可以解释3个因子1.2%、2.2%和2.1%的变异;不同性别在职业倦怠的情绪衰竭、去个性化因子上有统计学意义,95%的置信区间分别为(-0.03,-0.02)、(0.06,0.11)和(-0.03,0.02);高校教师与中小学教师相比,情绪衰竭、去个性化和低个人成就感因子差异均有统计学意义,95%的置信区间分别为(-0.08,-0.02)、(-0.03,-0.01)和(-0.04,-0.01);(-0.07,-0.04)、(-0.04,-0.02)和(-0.06,-0.02)。结论高校教师的职业倦怠情况逐年增加;男性教师的去个性化情况较女性教师严重,女性教师的情绪衰竭较男性教师严重;高校教师的职业倦怠显著轻于中小学教师。     

基于北斗卫星定位的伤员搜救与后送、远程医疗系统

目的:研制适合于一线救护的伤员搜救与后送、远程医疗系统,最大限度地实现医疗与士兵同在.方法:立足军队现有远程医疗技术,利用北斗卫星同时具备定位与双向通信的能力,设计一整套伤员搜寻、后送与远程医疗体系架构.结果:构建了基于北斗卫星定位的伤员搜救、后送与远程医疗平台设计方案.结论:解决了战场伤员精确定位、援救与后送的难题,满足了非战争军事行动卫勤保障的需要.     

关于中医院校研究生文献查找途径的调查

以浙江中医药大学高年级研究生60人为研究对象，进行问卷调查，调查其知晓利用文献查找途径的情况，对调查结果进行统计分析，找出医学专业研究生在文献查找途径中存在的问题，最后针对存在的问题提出切实可行的建议。     

Disorientation and Reconstruction

Abstract

This study examines psychosocial difficulties faced by Chinese patients with colorectal cancer, and attempts to identify factors that contribute to the meaning searching process that in turn brings about growth and transformation. Twenty-six patients with colorectal cancer were interviewed. Data were analyzed using the constant comparative method. Two domains of psychosocial disorientation states were identified, namely, cognitive disorientation and emotional disorientation. Factors that facilitate meaning searching were identified and categorized into personal factors and external factors. The areas of growth and transformation through meaning searching were presented with narratives. Findings from the present study not only shed light on psychosocial hindrances among colorectal cancer patients but also have the potential to inform the design of intervention strategies to bring about meaning-orientated transformation through cancer experiences.     

网络环境下护理专业文献检索课的教学改革

目的：文章探讨在网络环境下,针对护理专业特点,医学文献检索教学的改革。方法：从护理专业开设文献检索课的重要性入手,结合医学文献检索课的专业特点,具体分析文献检索课在教学内容、教学方法以及考试方式等方面的改革措施。结果：采取优化教材内容;改革教学模式以及重视实际操作的考试方式等形式开展检索教学。结论：实践表明,此种教学模式,对护理专业学生利用信息、整合信息的能力培养具有较好效果。